型号：GM-J#012445 -Cryorecovery

应用：These transgenic mice express the human LRRK2 gene and may be useful in studies of Parkinson's disease.

型号：GM-J#012444 -Cryorecovery

应用：This LRRK2 knock-out targeted mutation strain exhibits enhanced neuritic outgrowth and may be useful in studies of dendritic neuronal arborization and Parkinson's disease.

型号：GM-J#012442 -Cryorecovery

应用：These transgenic mice carry a humanized synuclein (alpha-syn) mutant (SNCA*A53T) gene regulated by a tetracycline operator (tetO). When mated to a mutant strain expressing tTA, expression of SNCA*A53T protein may be regulated with the tetracycline analog doxycycline in the double mutant offspring.

型号：GM-J#012441 -Cryorecovery

应用：These hemizygous transgenic mice carry a humanized leucine-rich repeat kinase 2 mutant gene, LRRK2*G2019S, regulated by a tetracycline operator (tetO). When mated to a mutant strain expressing tetracycline-controlled transactivator protein (tTA), expression of LRRK2*G2019S protein may be regulated with the tetracycline analog doxycycline (dox) in the double mutant offspring. These mice may be useful for studying the Parkinson's disease pathogenesis and neurodegeneration elicited by the dominant toxic effects of mutant LRRK2*G2019S expression.

型号：GM-J#012433 -Cryorecovery

应用：This HSA-rtTA/TRE-Cre mutant mouse strain may be useful for generating tissue specific-targeted mutants that would be useful in studying gene function in skeletal muscle, and is especially useful for studying steroid and hormone regulation in skeletal muscle and muscle/motorneuron interactions.

型号：GM-J#012429 -Cryorecovery

应用：The R26NZG targeting vector contains a loxP-flanked PGK-Neo-4x polyA STOP cassette, FRT-flanked a nuclear localized β-galactosidase (nlslacZ)-3x polyA, and enhanced green fluorescent protein (EGFP)-1x polyA. These mice may be useful as a Cre mediated reporter or a FLP reporter when expressed in cells/tissues where the expression patterns of the individual promoters driving CRE recombinase and FLP recombinase overlap.

型号：GM-J#012373 -Cryorecovery

应用：These Hoxb1 Cre recombinase knock-in mice may be useful for generating mutations to study fate mapping of cell lineages derived from rhombomere 4 (r4) of the hindbrain.

型号：GM-J#012365 -Cryorecovery

应用：These Dat bacTRAP mice express a EGFP/Rpl10a, green fluorescent protein-tagged ribosomal protein L10a, transgene under the control of the mouse Slc6a3 gene, in midbrain dopaminergic neurons. These mice may be useful in translational profiling (TRAP, translating ribosome affinity purification) studies related to Parkinson's Disease.

型号：GM-J#012362 -Available

应用：These Camk2a-CreERT2 transgenic mice express a tamoxifen-inducible Cre recombinase under the control of the mouse Camk2a (calcium/calmodulin-dependent protein kinase II alpha) promoter region, and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in subgroups of Camk2a-expressing neural tissues (including cortex, hippocampus, striatum, and other structures).

型号：GM-J#012361 -Cryorecovery

应用：The R26StopFLRACDA conditional allele is targeted to the Gt(ROSA)26Sor locus and has a loxP-flanked Neo-STOP cassette preventing transcription of the downstream bicistronic sequences (RACDA [RacG12V; a mutant form of Rac1 rendered constitutively active by a glycine->valine substitution at amino acid 12] and EGFP). These R26StopFLRACDA mice allow inducible constitutive activity of Rac1-dependent signal transduction; which is associated with gene expression, proliferation, cell survival, cell cycle progression, cytoskeletal reorganization, and Rho- and CDC42-pathways.