型号：GM-J#012859 -Cryorecovery

应用：These Neurog1457-Cre may be useful for generating conditional mutations in Neurog1 lineages in the central and peripheral nervous systems.

型号：GM-J#012849 -Available

应用：These GCE transgenic mice have a human glial fibrillary acidic protein (hGFAP) promoter sequence directing expression of a Cre-estrogen receptor (Cre-ERT2) fusion protein. When these transgenic mice are bred with mice containing a loxP-flanked sequence, tamoxifen-inducible Cre-mediated recombination is expected to result in deletion of the floxed sequences in the Cre recombinase-expressing tissues of the offspring.

型号：GM-J#012841 -Cryorecovery

应用：These GT.cre transgenic mice express Cre recombinase in cortical tubular epithelium of the kidney and may be useful for generating conditional mutations to study polycystic kidney disease and renal fibrosis.

型号：GM-J#012839 -Cryorecovery

应用：In Ox40-cre mice, the targeted mutation inserts an internal ribosome entry site (IRES)-Cre recombinase into exons 3 of the tumor necrosis factor receptor superfamily, member 4 (Tnfrsf4 or Ox40) locus, abolishing gene function. These mice are useful for inducing Cre-dependent genetic changes in OX40-expressing cells.

型号：GM-J#012837 -Available

应用：Lck-cre transgenic mice contain a Cre-recombinase gene driven by the distal promoter of the lymphocyte protein tyrosine kinase (Lck) gene. These mice are useful for studying the consequences of mutations induced after positive selection in the thymus.

型号：GM-J#012769 -Cryorecovery

应用：Thy1mγSN transgenic mice have the mouse thymus cell antigen 1 (Thy-1) promoter directing expression of the mouse γ-synuclein (Sncg) gene. These mice may be useful for studying the pathophysiology of Parkinson's disease, and other neurodegenerative disorders.

型号：GM-J#012735 -Cryorecovery

应用：The Ai35D (or Ai35Δneo) allele has a floxed-STOP cassette preventing transcription of the downstream Arch-GFP fusion gene. Exposure to Cre recombinase that deletes the STOP cassette results in Arch-GFP expression. These Ai35D mice are useful for optogenetic studies to express an inhibitory opsin that effectively silences the activity of cortical neurons (and perhaps other excitable cell types such as muscle cells and immune cells).

型号：GM-J#012710 -Cryorecovery

应用：The Cck-CreER (or Cck-CreERT2) knock-in allele both abolishes cholecystokinin (Cck) gene function and expresses the CreERT2 fusion protein in cholecystokinin positive cortical neurons (both interneurons and pyramidal neurons) as directed by the endogenous Cck promoter/enhancer elements. Cre-ERT2 fusion gene activity is inducible by the administration of tamoxifen.

型号：GM-J#012708 -Available

应用：These SLICK-H transgenic mice have expression of a CreERT2 fusion protein and an enhanced yellow fluorescent protein (EYFP) directed by two separate copies of the modified mouse Thy1 promoter region. These SLICK-H transgenic mice allow fluorescent labeling in the majority of projection neurons populations in the central and peripheral nervous system, with inducible Cre-lox genetic manipulation in the same widespread population of labeled neurons.

型号：GM-J#012706 -Available

应用：The Cck-IRES-Cre knock-in allele has an internal ribosome entry site and Cre recombinase in the 3' UTR of the cholecystokinin locus (Cck). As such, Cre recombinase expression is directed to Cck-expressing cells (cholecystokinin positive neurons) by the endogenous promoter/enhancer elements of the cholecystokinin locus.