型号：GM-J#021788 -Cryorecovery

应用：These H3f3ac/c mutant mice possess loxP sites flanking a wildtype H3 histone isoform 3 (H3.3) coding sequence and STOP sequence. When bred to mice expressing cre-recombinase, removal of the floxed sequence results in YFP expression. This strain may be useful for studying the role of histone H3.3 during development.

型号：GM-J#021777 -Cryorecovery

应用：The last coding exon (exon 24) of the Nrxn1 (neurexin 1) gene is flanked by loxP sites in this conditional mutant allele. Cre excision of the floxed segment enables the production of truncated protein. A 2xHA (hemagglutinin) tag outside of the floxed region provides a useful marker.

型号：GM-J#021614 -Available

应用：These MRP8-Cre-ires/GFP transgenic mice may be useful in studies utilizing "Cre-lox" technology or fluorescent protein expression in granulocytes and granulocyte/macrophage progenitors (GMPs).

型号：GM-J#021582 -Cryorecovery

应用：Mchr1-cre BAC transgenic mice have Cre recombinase expression directed to Mchr1-expressing neurons throughout the brain (including olfactory system, striatum, and hypothalamus). These Mchr1-cre BAC transgenic mice are useful to generate conditional mutations for studying energy balance/homeostasis, feeding behavior, weight loss, diet-induced obesity, olfactory behaviors, learning and memory, and the neuroanatomical distribution and neurochemical phenotype of melanin-concentrating hormone receptor 1-expressing cells.

型号：GM-J#021504 -Available

应用：These Vil1-cre mice express Cre recombinase in villus and crypt epithelial cells of the small and large intestines and may be useful in studies of intestinal organogenesis. In addition, Vil1-cre transgenic mice from founder line 1000 are reported to be absent of Cre recombinase activity in gonads.

型号：GM-J#021461 -Cryorecovery

应用：The MADM-12TG (Igs6TG) allele has the CMV enhancer/chicken beta-actin core promoter, the N-terminal portion of tdTomato, a beta-globin intronic sequence (containing an frt site and loxP site), and the C-terminal portion of mut4-EGFP all inserted into the Igs6 locus on chromosome 12 (~1.71 cM; ~16 kbp downstream of exon 1 of the Rab10 gene). These MADM-12TG mutants are designed for MADM (mosaic analysis with double markers), and must be crossed to MADM-12GT mice harboring a reciprocal mutation at the same locus (Stock No. 021460). This MADM system allows Cre recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation, mitosis, and imprinting.

型号：GM-J#021460 -Cryorecovery

应用：The MADM-12GT (Igs6GT) allele has the CMV enhancer/chicken beta-actin core promoter, the N-terminal portion of mut4-EGFP, a beta-globin intronic sequence (containing an frt site and loxP site), and the MYC-tagged C-terminal portion of tdTomato all inserted into the Igs6 locus on chromosome 12 (~1.71 cM; ~16 kbp downstream of exon 1 of the Rab10 gene). These MADM-12GT mutants are designed for MADM (mosaic analysis with double markers), and must be crossed to MADM-12TG mice harboring a reciprocal mutation at the same locus (Stock No. 021461). This MADM system allows Cre recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation, mitosis, and imprinting.

型号：GM-J#021458 -Cryorecovery

应用：The MADM-7TG (Igs5TG) allele has the CMV enhancer/chicken beta-actin core promoter, the N-terminal portion of tdTomato, a beta-globin intronic sequence (containing frt and lox sites), and the C-terminal portion of mut4-EGFP all inserted into the Igs5 locus on chromosome 7 (~2.13 cM; ~0.7 kbp downstream of exon 5 of the Rps9 gene). These MADM-7TG mutants are designed for MADM (mosaic analysis with double markers), and must be crossed to MADM-7GT mice harboring a reciprocal mutation at the same locus (Stock No. 021457). This MADM system allows Cre recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation, mitosis, and imprinting.

型号：GM-J#021457 -Cryorecovery

应用：The MADM-7GT (Igs5GT) allele has the CMV enhancer/chicken beta-actin core promoter, the N-terminal portion of mut4-EGFP, a beta-globin intronic sequence (containing frt and lox sites), and the MYC-tagged C-terminal portion of tdTomato all inserted into the Igs5 locus on chromosome 7 (~2.13 cM; ~0.7 kbp downstream of exon 5 of the Rps9 gene). These MADM-7GT mutants are designed for MADM (mosaic analysis with double markers), and must be crossed to MADM-7TG mice harboring a reciprocal mutation at the same locus (Stock No. 021458). This MADM system allows Cre recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation, mitosis, and imprinting.

型号：GM-J#021429 -Cryorecovery

应用：In this conditional Gt(ROSA)26Sor (gene trap ROSA 26, Philippe Soriano) knock-in strain, Cre excision of a floxed stop cassette enables expression of GFP that is specifically localized to mitochondria. A C-terminal V5 epitope tag is also fused to GFP.