型号：GM-J#022075 -Available

应用：Prox1-Cre-ERT2 mice express tamoxifen-inducible Cre recombinase in lymphatic endothelial cells.

型号：GM-J#022071 -Available Now

应用：CD4-Cre transgenic mice contain CD4 enhancer, promoter and silencer sequences driving the expression of a Cre recombinase gene. These mice may be useful for generating conditional mutations in CD4-expressing tissues.

型号：GM-J#021962 -Cryorecovery

应用：PITX3+/IRES2-tTA KI mice may be useful when studying the pathogenic mechanism of α-syn-dependent dopaminergic dysfunction.

型号：GM-J#021961 -Cryorecovery

应用：An internal ribosome entry site (IRES)-CreERT2 fusion protein and a polyadenylation signal were placed downstream of the endogenous stop codon of the ATP-binding cassette, sub-family G (WHITE), member 2 Abcg2 gene. These mice may be useful for hematopoietic lineage tracking.

型号：GM-J#021914 -Cryorecovery

应用：These Atp13a2 targeted mutation mice develop late-onset impaired motor function and behavior, as well as lipofuscinosis. This strain may be useful in studies related to synucleinopathies such as Parkinson's disease, and lysosomal storage disorders.

型号：GM-J#021913 -Cryorecovery

应用：These transgenic mice express a mutant human form of human leucine-rich repeat kinase 2 (LRRK2 ), containing an A->G transition (Y1699C), and may be useful in studies of Parkinson's disease.

型号：GM-J#021882 -Available

应用：The FosCreER knock-in/knockout allele was designed to both abolish expression of the Fos immediate early gene and direct expression of the CreERT2 fusion protein from the Fos promoter/enhancer elements. These mice are a Cre-lox tool that allows inducible Cre expression in Fos-expressing cells/tissues; including neurons activated by specific somatosensory, visual, and auditory stimuli. Immediate early genes (IEGs) are the connection between gene expression and a neuron's electrical/synaptic activity (which defines the neuron's response properties).

型号：GM-J#021881 -Cryorecovery

应用：The ArcCreER knock-in/knockout allele was designed to both abolish expression of the Arc immediate early gene and direct expression of the CreERT2 fusion protein from the Arc promoter/enhancer elements. These mice are a Cre-lox tool that allows inducible Cre expression in Arc-expressing cells/tissues; including neurons activated by specific somatosensory, visual, and auditory stimuli. Immediate early genes (IEGs) are the connection between gene expression and a neuron's electrical/synaptic activity (which defines the neuron's response properties).

型号：GM-J#021879 -Cryorecovery

应用：The Snap25-LSL-2A-EGFP-D (also called Snap25-LSL-2A-EGFP-Δ or Snap25-LSL-2A-EGFP-Δneo/hygro) conditional allele is designed with a loxP-flanked STOP cassette and enhanced green fluorescent protein (EGFP) downstream of the synaptosomal-associated protein 25 (Snap25) translational STOP codon. Following Cre recombinase removal of the floxed STOP cassette, EGFP fluorescence is expected in cells/tissues where the expression patterns of Snap25 and Cre recombinase overlap. Snap25 is a t-SNARE protein. These mice may be useful as a Cre-lox tool for fluorescent visualization of synaptic vesicle/plasma membrane fusion.

型号：GM-J#021878 -Cryorecovery

应用：Tac2-IRES2-Cre-D mice (also called Tac2-IRES2-Cre-Δ or Tac2-IRES2-Cre-Δneo/hygro) have both endogenous gene and Cre recombinase expression directed to Tac2-expressing cells by the endogenous promoter/enhancer elements of the tachykinin 2 locus. Tac2 encodes neurokinin B (NKB), a neuromodulator that plays a role in pain modulation. These mice may be useful to generate conditional mutations for studying gain or loss of function and/or mapping in the brain.