型号：GM-J#021877 -Available

应用：Tac1-IRES2-Cre-D mice (also called Tac1-IRES2-Cre-Δ or Tac1-IRES2-Cre-Δneo/hygro) have both endogenous gene and Cre recombinase expression directed to Tac1-expressing cells by the endogenous promoter/enhancer elements of the tachykinin 1 locus. Tac1 encodes neurokinin 1/substance P, a neurotransmitter that plays a role in behavior and pain modulation.

型号：GM-J#021876 -Cryorecovery

应用：Ai66(RCRL-tdT)Δneo (also called Ai66(RCRL-tdT)-D, Ai66Δneo, or Ai66D) is a dual Dre/Cre recombinase fluorescent reporter. This Rosa-CAG-RoxSTOPRox-LoxSTOPLox-tdTomato::deltaNeo conditional allele is designed with both a Rox-flanked STOP cassette and a loxP-flanked STOP cassette preventing transcription of the tdTomato fluorescent protein. After removal of the flanked STOP cassettes by Dre- and Cre-recombination, tdTomato fluorescence is expected in cells/tissues expressing both Dre recombinase and Cre recombinase.

型号：GM-J#021875 -Available

应用：Ai65(RCFL-tdT)Δneo mice (also called Ai65(RCFL-tdT)-D, Ai65Δneo, or Ai65D) harbor the Rosa-CAG-FrtSTOPFrt-LoxSTOPLox-tdTomato::deltaNeo conditional allele designed with both an frt-flanked STOP cassette and a loxP-flanked STOP cassette preventing transcription of the tdTomato fluorescent protein. After removal of the flanked STOP cassettes by FLP- and Cre-recombination, tdTomato fluorescence is expected in cells/tissues expressing both FLP recombinase and Cre recombinase.

型号：GM-J#021830 -Cryorecovery

应用：This strain carries the D1994A point mutation in the Parkinson's disease-related Lrrk2 gene. The LRRK2 D1994A mutant protein has been shown to inhibit kinase activity.

型号：GM-J#021829 -Cryorecovery

应用：This strain carries the T1348N point mutation in the Parkinson's disease-related Lrrk2 gene. The LRRK2 T1348N mutant protein has been shown to inhibit GTPase activity.

型号：GM-J#021828 -Cryorecovery

应用：This strain carries the A2016T point mutation in the Parkinson's disease-related Lrrk2 gene. The Lrrk2 A2016T mutant protein has been shown to have normal kinase enzyme activity, but is resistant to certain kinase inhibitors.

型号：GM-J#021827 -Cryorecovery

应用：These loxP-flanked knockin mice carry an amino acid substitution, R1207H in exon 24, as well as loxP sites flanking exons 24 to 28 of the Eif4g1 gene. Mutations in Eif4g1, a translation initiation factor, are associated with susceptibility to Parkinson's disease.

型号：GM-J#021807 -Cryorecovery

应用：These mutant mice carry a Cre recombinase inducible D620N mutation in exon 15 of the Vps35 (vacuolar protein sorting 35) gene and may be useful in studies of Parkinson's disease.

型号：GM-J#021794 -Cryorecovery

应用：In this targeted mutant strain, an EGFP-Cre knock-in ablates expression of the mouse Ascl3 achaete-scute complex homolog 3 (Drosophila) gene. Fluorescent labeling and Cre expression recapitulate endogenous Ascl3 expression, useful in studies of salivary gland development and maintenance.

型号：GM-J#021789 -Cryorecovery

应用：These H3f3bc/c mutant mice possess loxP sites flanking a wildtype H3 histone isoform 3 (H3.3) coding sequence and STOP sequence. When bred to mice expressing cre-recombinase, removal of the floxed sequence results in CFP expression. This strain may be useful for studying the role of histone H3.3 during development.