型号：GM-J#025110 -Cryorecovery

应用：Fezf1-2A-dCre-D mice express a trimethoprim-inducible Cre recombinase directed to Fezf1-expressing cells by the endogenous promoter/enhancer elements of the Fez family zinc finger 1 locus. When induced, small increases in Cre recombinase activity are observed in restricted populations within striatum and hypothalamus, as well as scattered positive cells in amygdala and cortex.

型号：GM-J#025109 -Cryorecovery

应用：The Ai80(RCFL-CatCh)-D (or Ai80D) conditional allele has both an frt-flanked STOP cassette and a loxP-flanked STOP cassette preventing transcription of the calcium translocating channelrhodopsin (CatCh; an L132C mutant channelrhodopsin with enhanced Ca2+ permeability, accelerated response kinetics and ~70-fold greater light sensitivity) and EYFP. After removal of the flanked STOP cassettes by FLP- and Cre-recombination, CatCh/EYFP expression is expected in cells/tissues expressing both FLP recombinase and Cre recombinase. Subsequent illumination of CatCh-expressing cells with blue-to-green light leads to reversible photostimulation of action potential firing/neural activity in these cells.

型号：GM-J#025106 -Available

应用：Ai75(RCL-nT)-D (also called Ai75D or Ai75(RCL-nls tdT)-D) mice display nuclear-localized tdTomato fluorescence following Cre recombinase exposure.

型号：GM-J#025105 -Cryorecovery

应用：When these CaMKIIα-tTA transgenic mice are mated to strain carrying a gene of interest under the regulatory control of a tetracycline-responsive promoter element (TRE; tetO), expression of the target gene can be blocked by administration of the tetracycline analog, doxycycline. These mice are a "Tet-Off" tool that allow the inducible expression of genes in forebrain neurons, and may be useful in studying brain disorders such as Alzheimer's, Parkinson's, Huntington's, or other neurodegenerative disease.

型号：GM-J#024968 -Cryorecovery

应用：This tamoxifen-inducible Pdx1-Cre/Esr1 strain may be used to create conditional pancreatic cell knockouts when crossed with strains carrying floxed alleles.

型号：GM-J#024948 -Cryorecovery

应用：The GdnfCreERT2 allele expresses GDNF and tamoxifen-inducible CreERT2 in self-renewing, multipotent renal progenitor cells. These mice may be useful for studying the role of GDNF on ureteric bud branching and fetal nephron numbers in the developing kidney.

型号：GM-J#024926 -Cryorecovery

应用：These mice express Cre recombinase under the control of a truncated follicle stimulating hormone receptor (Fshr) promoter in ovarian granulosa cells and in cells from the anterior pituitary.

型号：GM-J#024864 -Cryorecovery

应用：These MIC transgenic mice express activated PyVT (Polyomavirus middle T antigen) and Cre recombinase under the control of a tetracycline-responsive promoter element (TRE or tetO) and are an effective tool for generating inducible, tissue-specific, targeted mutants to study polyomavirus middle T antigen (PyV mT)-mediated mammary tumorigenesis.

型号：GM-J#024849 -Cryorecovery

应用：The Thy1.2-Cre enhancer trap transgenic mouse line 09 (TFC.09) expresses Cre recombinase sparsely in a small number of cortical progenitor cells during early forebrain development. GFP expression is almost undetectable by fluorescence and it is only transiently expressed in a few stem cells in the embryo. TFC.09 mice allow examination of individual columns and cells, and may be useful for investigating patterns of neural development in the neocortex, as well as for studying cell lineage in mouse brain.

型号：GM-J#024846 -Cryorecovery

应用：ReaChR protein (a red-shifted channelrhodopsin) was tagged with mCitrine fluorescent protein and placed under the conditional control of the Gt(ROSA)26Sor promoter. Excision of two stop cassettes (one flanked by loxP sites, another flanked by FRT sites) enables fluorescent expression. As an optogenetic tool, this strain is useful for the selective activation and mapping of neuron populations.