型号：GM-J#026942 -Available

应用：RC::FL-hM3Dq is a dual recombinase-responsive Gq-coupled DREADD allele with a frt-flanked STOP and a cre-dependent FLEx switch containing an eGFP sequence and an inverted hM3Dq/mCherry/2ACT88 fusion protein. Flp-recombinase results in widespread, robust eGFP fluorescence, and further exposure to Cre recombinase may replace eGFP expression with somatodendritic hM3Dq/mCherry expression. The DREADD hM3Dq induces the canonical Gq pathway (depolarization/activation) specifically following administration of its pharmacologically inert ligand (CNO). The RC::FL-hM3Dq allele and its derivatives permit chemogenetic/pharmacogenetic activation of an intersectional subpopulation defined by overlap of Flp and Cre recombinase expression.

型号：GM-J#026932 -Available

应用：The RC::FLTG dual-recombinase responsive indicator allele is designed with a frt-flanked STOP and loxP-flanked tdTomato::STOP all preventing transcription of eGFP. Flp recombinase results in high tdTomato fluorescence, and further exposure to Cre recombinase results in robust eGFP fluorescence. The RC::FLTG allele and its derivatives are useful for fluorescent labeling of cells/tissues in embryonic or adult mice. These mice allow intersectional genetic fate mapping of different cell subpopulations defined by the overlap of two gene expression domains.

型号：GM-J#026931 -Available For Registering Interest

应用：This strain is currently unavailable due to replenishing of cryopreserved stocks.  Interested customers can register interest.

型号：GM-J#026930 -Cryorecovery

应用：The RC::RFLTG triple-recombinase responsive indicator allele is designed with a rox-flanked STOP, frt-flanked STOP and loxP-flanked tdTomato::STOP all preventing transcription of eGFP. Dre- and FLP-recombinase result in high tdTomato fluorescence, and further exposure to Cre recombinase results in robust eGFP fluorescence. The RC::RFLTG allele and its derivatives (e.g., dual-recombinase responsive and single-recombinase responsive) are useful for fluorescent labeling of cells/tissues in embryonic or adult mice. These mice allow intersectional genetic fate mapping of different cell subpopulations defined by the overlap of three gene expression domains.

型号：GM-J#026925 -Available

应用：K19CreERT knock-in/knock-out mice may be useful for applications requiring tamoxifen-induced deletion of floxed sequences in KRT19-expressing epithelial cells.

型号：GM-J#026880 -Cryorecovery

应用：These Nkx2-2:Cre-EGFP Knockin/knockout mice may have applications in studies requiring conditional gene manipulation or lineage fate mapping in the CNS, pancreas and intestine.

型号：GM-J#026863 -Cryorecovery

应用：These Gt(ROSA)26Sortm1Sor targeted mutant mice carry a loxP flanked neo cassette upstream of a β-galactosidase (lacZ) sequence. Removal of the neo cassette by cre recombination results in lacZ expression in cre-expressing tissues of the offspring. These mutant mice may be used as a Cre-reporter strain; to test the tissue/cellular expression pattern of cre transgenic mice.

型号：GM-J#026862 -Cryorecovery

应用：ROSAmT/mG is a cell membrane-targeted, two-color fluorescent Cre reporter allele; expressing cell membrane-localized red fluorescence in widespread cells/tissues prior to Cre recombinase exposure, and cell membrane-localized green fluorescence in Cre recombinase expressing cells (and future cell lineages derived from these cells). These ROSAmT/mG mice function similarly to ROSAnT-nG mice (Stock No. 023035), with ROSAmT/mG directed to cell membrane and ROSAnT-nG directed to nuclei.

型号：GM-J#026861 -Cryorecovery

应用：The LysMcre knock-in/knockout allele has a nuclear-localized Cre recombinase inserted into the first coding ATG of the lysozyme 2 gene (Lyz2); both abolishing endogenous Lyz2 gene function and placing NLS-Cre expression under the control of the endogenous Lyz2 promoter/enhancer elements. These LysMcre mice may be useful for Cre-lox studies of the myeloid cell lineage (monocytes, mature macrophages and granulocytes) and the innate immune response.

型号：GM-J#026860 -Cryorecovery

应用：Mice harboring the Tg(Tek-cre)2352Rwng (Tie2Cre) transgene express the Cre recombinase under the control of the mouse Tek, endothelial-specific receptor tyrosine kinase (also known as Tie2), promoter and may be useful for generating endothelial cell specific-targeted conditional mutations.