型号：GM-J#027234 -Cryorecovery

应用：The high-activity Notch1 activation-dependent reporter knock-in allele, N1IP::CreHI, has the endogenous Notch1 intracellular domain (NICD1) replaced with a nuclear-localized Cre recombinase. Compared to N1IP::CreLO, this N1IP::CreHI allele has significantly improved sensitivity with five- to ten-fold increase in Cre activity. This improved sensitivity allows users to label cells experiencing moderate-to-lower Notch activation thresholds; including most cells/tissues known to utilize Notch1 during their development and/or maintenance.

型号：GM-J#027214 -Cryorecovery

应用：These TrkBCreER mutant mice express Cre-ERT2 from the mouse Ntrk2 promoter. Endogenous NTRK2 expression is knocked out. Treatment with 4-hydroxytamoxifen (OHT) enables the Cre-mediated excision of introduced floxed sequences in dorsal root ganglion neurons.

型号：GM-J#027205 -Cryorecovery

应用：These Nms-iCre mice express codon-improved Cre recombinase in a subset of Nms-expressing neurons in the suprachiasmatic nucleus and may be useful in studying circadian rhythms and behavior.

型号：GM-J#027178 -Cryorecovery

应用：These DAT-PF-tTA mice conditionally express tetracycline responsive transactivator (tTA) in dopamine neurons from the mouse Slc6a3 (DAT) promoter. A “PF” (tetO-tTA) positive feedback cassette is incorporated in the construct to amplify tTA expression. Homozygotes have little or no endogenous SLC6A3/DAT expression and show growth retardation. These mice may be useful for studying gene function in dopaminergic neurons, such as drug addiction, Parkinson's disease and Attention Deficit-Hyperactivity Disorder (ADHD).

型号：GM-J#027116 -Cryorecovery

应用：CD19creERT2 mice express tamoxifen-inducible Cre recombinase under the direction of the Cd19 promoter in B lymphocytes.

型号：GM-J#027039 -Cryorecovery

应用：These Grem1-creERT mice express a tamoxifen-inducible Cre recombinase under the control of the mouse Grem1 promoter. When bred with mice containing loxP-flanked sequences, tamoxifen-inducible Cre-mediated recombination will result in deletion of the floxed sequences in the Grem1-expressing cells of the offspring. These mice may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in bone marrow osteochondroreticular stem cells (skeletal stem cells), and intestinal reticular stem cells.

型号：GM-J#027012 -Cryorecovery

应用：These Foxj1CreERT2::GFP knock-in/knock-out mice express GFP and tamoxifen inducible Cre recombinase in epithelial cells with motile cilia. They are suitable for use in applications related to the study of ciliogenesis, as well as lineage tracing of Foxj1 expressing cells.

型号：GM-J#026975 -Cryorecovery

应用：These edn2-iCre transgenic mice have the mouse endothelin 2 (Edn2) promoter driving codon optimized iCre recombinase expression in the epidermis, ovary (capsule, stromal cells, corpora lutea, granulosa cells), testicular interstitium, coagulation gland (anterior prostate), and preputial gland.

型号：GM-J#026944 -Cryorecovery

应用：The RC::L-DTA allele has a cre-dependent FLEx switch containing an eGFP sequence and an inverted tox176 attenuated diphtheria toxin subunit alpha gene (DTA*G128D) that are uniquely flanked/separated by inward-facing lox sites (both lox2272 and loxP). Widespread eGFP fluorescence is observed in the absence of Cre recombinase. Subsequent exposure to Cre recombinase that places the DTA*G128D into the proper orientation for expression results in ablation of those cells.

型号：GM-J#026943 -Cryorecovery

应用：RC::L-hM3Dq is a Gq-coupled DREADD allele with a cre-dependent FLEx switch containing an eGFP sequence and an inverted hM3Dq/mCherry/2ACT88 fusion protein. Upon exposure to Cre recombinase, the widespread and robust eGFP fluorescence may be replaced with somatodendritic hM3Dq/mCherry expression. The hM3Dq DREADD induces the canonical Gq pathway (depolarization/activation) specifically following administration of its pharmacologically inert ligand (CNO). The RC::L-hM3Dq allele and its derivatives permit chemogenetic/pharmacogenetic activation defined by Cre recombinase expression.