型号：GM-J#032033-JAX -Cryorecovery

应用：The SIRT1STOP (or SIRT1-Tg flox-STOP-flox) targeted allele has a floxed-STOP cassette and mouse sirtuin 1 (Sirt1) cDNA sequence inserted into the 3' UTR of the collagen A1 (Col1a1) locus. When bred to mice that express Cre recombinase, offspring will have the floxed-STOP cassette deleted in the cre-expressing tissue(s), resulting in Sirt1 overexpression. These SIRT1STOP (or SIRT1-Tg flox-STOP-flox) mice may be useful for generating conditional mutations for studying the role of sirtuin NAD+-deacetylases in aging, cancer, cellular stress resistance, genomic stability, IGF1 pathways, autoimmunity, inflammation, T cell tolerance, energy metabolism, neurodegeneration, insulin resistance, and diabetes.

型号：GM-J#032027 -Available

应用：Advillin-CreERT2 transgenic mice (AvCreERT2) express a tamoxifen-inducible iCre recombinase directed by mouse Avil (advillin) promoter elements. When induced, iCre recombinase activity is observed in dorsal root ganglia and sensory neurons. These mice may have applications in the study of nociception.

型号：GM-J#031971 -Cryorecovery

应用：Cre-mediated excision of a floxed Stop in these LSD1 VN mice enables expression of FLAG-tagged human KDM1A (LSD1) cDNA encoding LSD1n isoforms of the gene, as well as an EGFP fluorescent reporter. These mice have been used for chromatin immunoprecipitation (ChIP) analysis.

型号：GM-J#031970 -Cryorecovery

应用：Cre-mediated excision of a floxed Stop in these LSD1 WT mice enables expression of FLAG-tagged human KDM1A (LSD1) cDNA encoding LSD1c isoforms of the gene, as well as an EGFP fluorescent reporter. These mice have been used for chromatin immunoprecipitation (ChIP) analysis.

型号：GM-J#031934 -Cryorecovery

应用：HSA-MCM mice express tamoxifen-inducible cre in both limb and craniofacial skeletal muscles.

型号：GM-J#031863 -Cryorecovery

应用：AadcS250F/S250F mice carry a conserved C890T base pair (S250F amino acid) mutation in the mouse Ddc gene. This mutation corresponds to a human C835T missense mutation associated with infantile Parkinsonism.

型号：GM-J#031820 -Available

应用：Tmem119-2A-CreERT2 knock-in mice have the endogenous transmembrane protein 119 (Tmem119) promoter/enhancer sequences directing expression of tamoxifen-inducible Cre recombinase primarily in microglia, and are also designed to retain endogenous Tmem119 expression. These mice allow specific and inducible genetic manipulations in vivo for studying the function of resident microglia in the central nervous system during neuroinflammatory and neurological disease/injury, and may also be useful for investigating bone development, osteoblast differentiation and osteosarcoma.

型号：GM-J#031799 -Cryorecovery

应用：Pbrm1lacZ mice express a β-galactosidase gene and are null for Pbrm1, in addition, exon 4 is flanked by loxP sites in this conditional knock-out-first strain. These mice may be useful in studies of clear cell renal carcinoma and von Hippel-Lindau syndrome.

型号：GM-J#031779 -Cryorecovery

应用：Cyp19a1-Cre BAC transgenic mice express cre recombinase from the mouse Cyp19a1 (aromatase) promoter, faithfully recapitulating brain expression patterns of the endogenous mouse gene.

型号：GM-J#031776 -Cryorecovery

应用：TB (tTA2-BFP) mice have a floxed-STOP cassette preventing transcription of the downstream genes - tTA2 (tetracycline-controlled transactivator) and mTagBFP (nuclear-targeted monomeric blue fluorescent protein). TB mice are useful for Cre-dependent Tet-Off applications, as well as a Cre-dependent fluorescent reporter tool strain.