型号：GM-J#037071 -Cryorecovery

应用：MDRCas9 double mutant mice contain the 14qC3-MDR allele (Stock No. 017642), containing a loxP- and frt-flanked region on Chr 14 that has been implicated in B cell chronic lymphocytic leukemia (CLL). They also contain a Rosa26-LSL-Cas9 knockin allele (Stock No. 026175) with cre recombinase-dependent expression of CRISPR associated protein 9 (cas9) endonuclease and EGFP directed by a CAG promoter. When bred to MDRCD19 double homozygous mice (Stock No. 037070), these mice have applications in studies related to tumorigenesis and therapeutic management of chronic lymphocytic leukemia.

型号：GM-J#037070 -Cryorecovery

应用：MDRCD19 double mutant mice contain the 14qC3-MDR allele (Stock No. 017642), containing a loxP- and frt-flanked region on Chr 14 that has been implicated in B cell chronic lymphocytic leukemia (CLL). They also contain a Cd19cre allele (Stock No. 006785) with cre expression in B-lymphocytes during development and differentiation. When bred to MDRCas9 double homozygous mice (Stock No. 037071), these mice have applications in studies related to tumorigenesis and therapeutic management of chronic lymphocytic leukemia.

型号：GM-J#037052 -Available

应用：BAC-Sprr2f-Cre transgenic mice express Cre recombinase under the control of the Sprr2f promoter. They may be useful for driving expression of Cre specifically in endometrial epithelium.

型号：GM-J#037028 -Available

应用：CalcrCre mice have the endogenous calcitonin receptor (Calcr) promoter/enhancer sequences directing expression of Cre recombinase. These mice are a Cre-lox tool allowing Cre recombination in Calcr-expressing cells/tissues (including neurons of the nucleus of the solitary tract, hypothalamus, and lateral reticular nucleus) and may be useful for studying feeding behavior, obesity, and metabolism.

型号：GM-J#037018 -Available

应用：Removal of this mouse colony is imminent. If live mice are needed for your studies, it is advised that they be ordered immediately. After removal, the mice will be available from a cryorecovery.

型号：GM-J#037017 -Available

应用：CckarCre CRISPR-derived knock-in mice are designed to have 2A-Cre sequence inserted into the 3' UTR of the cholecystokinin A receptor (Cckar) gene. The endogenous Cckar promoter/enhancer regions direct expression of Cre recombinase to parts of the reproductive system, the central and peripheral nervous systems, and the gut, without disrupting endogenous gene expression. These mice are useful for studying mating behaviors, food intake, pancreatic exocrine secretion, gall bladder contractility and GI motility.

型号：GM-J#036980-JAX -Cryorecovery

应用：Mice homozygous for the null Dnajc6 or auxilin (DnaJ (Hsp40) homolog, subfamily C, member 6) allele exhibit high mortality at birth, decreased female fertility, an increase of assembled clathrin on vesicles and a decreased ratio of vesicle endocytosis at hippocampal synapses. This strain may be useful for studying synaptic vesicle recycling and early-onset Parkinson's.

型号：GM-J#036977 -Cryorecovery

应用：Albino DbpKI;tyr conditional circadian reporter mice express firefly luciferase upon Cre recombinase-mediated excision of a loxP-flanked destabilized GFP (d2EGFP) cassette. This CRISPR/Cas9-generated knock-in allele enables the in vivo and ex vivo assessment of bioluminescent rhythms in specific cellular populations.

型号：GM-J#036976 -Cryorecovery

应用：Krt5-CreERT2 knock-in mice have both endogenous gene and tamoxifen-inducible Cre recombinase expression directed to basal epithelial cells by the endogenous promoter/enhancer elements of the keratin 5 locus. These mice may be useful in generating conditional alleles for studying basal cells, cancer and epidermolysis bullosa.

型号：GM-J#036975 -Cryorecovery

应用：The R26R-Confetti conditional allele has a CAG promoter followed by a floxed-STOP cassette and the Brainbow 2.1 construct all targeted into the Gt(ROSA)26Sor locus. The R26R-Confetti allele functions as a stochastic multicolor Cre recombinase reporter of multiple fluorescent proteins from a single genomic locus. These R26R-Confetti mice allow a way to label and distinguish individual / adjacent cells with nuclear localized, membrane-targeted, or cytoplasmic fluorescent proteins in cre recombined cells.