型号：GM-J#008200 -Cryorecovery

应用：These piGAP transgenic reporter mice have expression of the eGFP-F-IRES-hPLAP dicistronic gene blocked by an upstream loxP-flanked STOP-polyA sequence. When bred to mice that express Cre recombinase, the resulting offspring will have the STOP-polyA sequence deleted in the cre-expressing tissue(s), permitting dicistronic expression of human Placental Alkaline Phosphatase (PLAP or ALPP) and farnesylated Enhanced Green Fluorescent Protein (eGFP-F; optimized to target expression to the cytoplasmic side of the plasma membrane). These piGAP transgenic reporter mice allow Cre-inducible, eGFP-F and hPLAP expression in multiple cell and tissue types.

型号：GM-J#008199 -Cryorecovery

应用：These Dlx5/6-Cre transgenic mice have Cre recombinase expression directed by the regulatory sequences of the zebrafish dlx5a/dlx6a genes and may be useful in generating specific deletions of floxed alleles in GABAergic in forebrain and other brain regions.

型号：GM-J#008135 -Cryorecovery

应用：Hemizygous transgenic mice are viable and fertile and develop a Parkinson-like phenotype upon aging. Hind limb paralysis due to loss of motor neurons and a resting tremor are initially seen at about six months of age. No Lewy body-like pathology is noted. Cell death in the spinal cord (extensive) and brain are observed.

型号：GM-J#008134 -Cryorecovery

应用：The A30P mutation in this transgenic strain is associated with the development of familial Parkinson's disease. The onset of hind limb mobility problems occurs around 12 months of age (sometimes earlier), induced by a loss of motor neurons and associated with the formation of insoluble alpha synuclein aggregates. This strain may be useful in studies of Parkinson's disease.

型号：GM-J#008133 -Cryorecovery

应用：These mice possess loxP sites on either side of exon 2 of the targeted gene. Mice that are homozygous for this allele are viable, normal in size and do not display any gross physical or behavioral abnormalities, but breed very poorly. Protein levels are normal. When bred to a strain expressing Cre recombinase, this mutant mouse strain may be useful in studies of presynaptic proteins and synaptic vesicles.

型号：GM-J#008132 -Cryorecovery

应用：M1m transgenic mice overexpress wildtype mouse Snca (synuclein, alpha) cDNA under the control of a mouse Thy1 (thymus cell antigen 1, theta) promoter. Mice hemizygous for this transgene are viable and fertile and do not display any gross physical or behavioral abnormalities, even upon aging.

型号：GM-J#008122 -Cryorecovery

应用：When these RIP-CreER mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in pancreatic beta cells. This mutant mouse strain may be useful in studying pancreatic development, diabetes and obesity.

型号：GM-J#008119 -Cryorecovery

应用：When these Ngn3/CreERTM mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Neurog3 expressing cells such as pancreatic islet cells and undifferentiated spermatogonia. This mutant mouse strain may be useful for studying pancreatic development and lineage mapping of Neurog3 expressing cells.

型号：GM-J#008085 -Cryorecovery

应用：The UBC-Cre-ERT2 transgenic strain backcrossed 11 or more generations to C57BL/6 is available as Stock No. 007001. The UBC-Cre-ERT2 transgenic strain backcrossed ~6 or more generations to C57BL/6 (Stock No. 008085) is available via cryo recovery.

型号：GM-J#008084 -Cryorecovery

应用：These D4R-mutant mice harbor a dopamine receptor 4 (Drd4; also called dopamine D4 receptor (D4R)) targeted mutation where exon 2 is replaced with a neomycin resistance cassette, and may be useful in studying dopamine/neurotransmitter function, drug addiction, Parkinson's disease, and schizophrenia or other psychoses.