型号：GM-J#008538 -Available

应用：These NG2CreERTM BAC transgenic mice express a tamoxifen-inducible Cre recombinase (CreERTM) under the control of the mouse NG2 (Cspg4) promoter/enhancer. When bred with mice containing loxP-flanked sequences, tamoxifen-inducible Cre-mediated recombination is expected to result in deletion of the floxed sequences in the Cre recombinase-expressing tissues of the offspring. These NG2CreERTM BAC transgenic mice may be useful for inducible Cre recombinase expression in NG2-expressing glia (polydendrocytes, oligodendrocyte progenitor cells) in the central nervous system and NG2-expressing cells in other organs.

型号：GM-J#008537 -Cryorecovery

应用：Mice harboring the Tg(Tek-cre)2352Rwng (Tie2Cre) transgene express the Cre recombinase under the control of the mouse Tek, endothelial-specific receptor tyrosine kinase (also known as Tie2), promoter and may be useful for generating endothelial cell specific-targeted conditional mutations.

型号：GM-J#008535 -Available

应用：These transgenic mice express a codon-improved Cre recombinase (iCre) under the control of the mouse Pf4 (platelet factor 4), or Cxcl4, promoter. Cre recombinase expression is detected in the majority of megakaryocytes, as well as in borderzone macrophages in the CNS. This strain represents an effective tool for generating megakaryocyte lineage-restricted specific-targeted mutants.

型号：GM-J#008533 -Cryorecovery

应用：These transgenic mice express the Cre recombinase under the control of the mouse chondroitin sulfate proteoglycan 4 (Cspg4) promoter/enhancer. Cre recombinase expression is detected in Cspg4 expressing glial cells and vasculature throughout the brain as well as in Cspg4-expressing cells in other tissues from late embryonic stages (~embryonic day 14) throughout adulthood. These transgenic mice may be may be crossed to various floxed mutants to delete floxed sequences specifically in Cspg4-expressing cells.

型号：GM-J#008532 -Cryorecovery

应用：These knock-in mice express a tamoxifen-inducible cre recombinase. When induced, cre activity is observed in dopaminergic neurons in the brain.

型号：GM-J#008531 -Cryorecovery

应用：This creER knock-in line can be used to produce Vamp2 (vesicle-associated membrane protein 2) gene recombination in many diverse types of neurons following 4-hydroxytamoxifen treatment. Heterozygotes are normal in size and viability. Homozygotes of both genders have reduced viability.

型号：GM-J#008529 -Cryorecovery

应用：When these Ngn1-CreERT2 transgenic mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Neurog1 expressing cells such as neurons in the cortex, hippocampus, thalamus, hypothalamus and the cochlear-vestibular ganglion. This mutant mouse strain may be useful for studying neuron development and lineage mapping of Neurog1 expressing cells.

型号：GM-J#008523 -Cryorecovery

应用：These 129S6 Podocin-Cre mice (harboring the p2.5P-Cre transgene) have expression of Cre recombinase directed to podocytes within kidney glomeruli by the human podocin (NPHS2) promoter/enhancer region and may be useful in generating Cre-lox conditional knockouts for studying the role of podocyte nephrobiology in renal disorders.

型号：GM-J#008520 -Cryorecovery

应用：Mice harboring the hCD2-iCre transgene have the human CD2 promoter and locus control region (LCR) directing expression of an optimized variant of Cre recombinase (iCre) to T cells and B cells (all B cell and T cell progenitors) and mice may be useful for generating conditional mutations in T cells and B cells. Because of the integration site of the transgene, the hCD2-iCre transgene is linked to the agouti coat color genes.

型号：GM-J#008516 -Cryorecovery

应用：Homozygous ROSA26 GNZ knock-in mice have widespread expression of a nuclear-localized green fluorescent protein/beta-galactosidase fusion protein (GFP-NLS-lacZ or GNZ) once an upstream loxP-flanked STOP sequence is removed. When bred to cre expressing mice, the resulting GNZ fusion protein expression in the offspring allows for enhanced (single cell level) visualization.