型号：GM-J#008333 -Cryorecovery

应用：These Dld (dihydrolipoamide dehydrogenase or E3 component) mutant mice may be useful to study early murine embryonic metabolism, including glucose and mitochondrial metabolism during the early postimplantation period. As altered energy metabolism and reductions in alpha-ketoacid dehydrogenase complexes have also been associated with many neurodegenerative disorders, these mice may also be useful in studies related to Parkinson's disease, Huntington's disease, and/or Alzheimer's disease. Because the metabolic disturbances associated with E3 deficiency (Dld deficiency) cause a variant of Maple Syrup Urine Disease (MSUD) in which there is an accompanying lactic acidosis due to concomitant deficiency of pyruvate dehydrogenase complex, these mice may be useful in such studies or in conjunction with iMSUD mice (Stock No. 006999).

型号：GM-J#008330 -Cryorecovery

应用：A melanocortin 4 receptor (Mc4r) promoter drives expression of Cre in this transgenic line. When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination occurs in all cells normally expressing MC4R.

型号：GM-J#008320 -Available

应用：Cre activity is demonstrable in the hypothalamus, limbic and cortical brain regions, and retrosplenial cortex of these knock-in Lepr mice. When bred with a mouse containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked genome in tissues that normally express the targeted gene. This strain has been used in virus-assisted mapping of neural inputs and may be useful in studies of neural features of feeding behaviors.

型号：GM-J#008314 -Cryorecovery

应用：These transgenic mice express Cre recombinase under the control of the human beta hemoglobin (HBB) promoter and intron 2-enhancer fragment, and the human beta hemoglobin locus control region (LCR). When crossed with a strain containing a loxP site-flanked sequence, Cre-mediated recombination results in deletion of the targeted sequence in erythroid tissues. These Cre recombinase expressing mutant mice may be useful in generating tissue specific-targeted mutants useful in studies of erythropoiesis and hematopoiesis.

型号：GM-J#008303 -Cryorecovery

应用：This Tcfe2a, transcription factor E2a, targeted mutation strain may be useful in generating conditional mutations for studying B and T cell development and for other immunological applications.

型号：GM-J#008245 -Cryorecovery

应用：These hwα-SYN-5 transgenic mice may be useful for studying Parkinson's disease, Lewy bodies, neurodegeneration, and synaptic plasticity in conjunction with Stock No. 008239.

型号：GM-J#008244 -Cryorecovery

应用：This strain represents an effective tool for generating inducible, tissue-specific-targeted mutants to study cell lineage during development.

型号：GM-J#008239 -Cryorecovery

应用：These transgenic mice, sometimes referred to as hm2α-SYN-39, contain a mutated human alpha synuclein protein found in human Parkinson Disease patients and under the control of the rat tyrosine hydroxylase promoter. Expression is detected in cell bodies, axons, and terminals of the nigrostriatal system.

型号：GM-J#008226 -Cryorecovery

应用：These piGAP transgenic reporter mice have expression of the eGFP-F-IRES-hPLAP dicistronic gene blocked by an unpstream loxP-flanked STOP-polyA sequence. When bred to mice that express Cre recombinase, the resulting offspring will have the STOP-polyA sequence deleted in the cre-expressing tissue(s),

型号：GM-J#008208 -Cryorecovery

应用：These Stra8-cre transgenic mice have expression of Cre recombinase (iCre) directed by the Stra8 genomic promoter fragment, and may be useful in generating conditional knockouts in postnatal, premeiotic, male germ cells for studying spermatogenesis.