型号：GM-J#021881 -Cryorecovery

应用：The ArcCreER knock-in/knockout allele was designed to both abolish expression of the Arc immediate early gene and direct expression of the CreERT2 fusion protein from the Arc promoter/enhancer elements. These mice are a Cre-lox tool that allows inducible Cre expression in Arc-expressing cells/tissues; including neurons activated by specific somatosensory, visual, and auditory stimuli. Immediate early genes (IEGs) are the connection between gene expression and a neuron's electrical/synaptic activity (which defines the neuron's response properties).

型号：GM-J#021879 -Cryorecovery

应用：The Snap25-LSL-2A-EGFP-D (also called Snap25-LSL-2A-EGFP-Δ or Snap25-LSL-2A-EGFP-Δneo/hygro) conditional allele is designed with a loxP-flanked STOP cassette and enhanced green fluorescent protein (EGFP) downstream of the synaptosomal-associated protein 25 (Snap25) translational STOP codon. Following Cre recombinase removal of the floxed STOP cassette, EGFP fluorescence is expected in cells/tissues where the expression patterns of Snap25 and Cre recombinase overlap. Snap25 is a t-SNARE protein. These mice may be useful as a Cre-lox tool for fluorescent visualization of synaptic vesicle/plasma membrane fusion.

型号：GM-J#021878 -Cryorecovery

应用：Tac2-IRES2-Cre-D mice (also called Tac2-IRES2-Cre-Δ or Tac2-IRES2-Cre-Δneo/hygro) have both endogenous gene and Cre recombinase expression directed to Tac2-expressing cells by the endogenous promoter/enhancer elements of the tachykinin 2 locus. Tac2 encodes neurokinin B (NKB), a neuromodulator that plays a role in pain modulation. These mice may be useful to generate conditional mutations for studying gain or loss of function and/or mapping in the brain.

型号：GM-J#021877 -Available

应用：Tac1-IRES2-Cre-D mice (also called Tac1-IRES2-Cre-Δ or Tac1-IRES2-Cre-Δneo/hygro) have both endogenous gene and Cre recombinase expression directed to Tac1-expressing cells by the endogenous promoter/enhancer elements of the tachykinin 1 locus. Tac1 encodes neurokinin 1/substance P, a neurotransmitter that plays a role in behavior and pain modulation.

型号：GM-J#021876 -Cryorecovery

应用：Ai66(RCRL-tdT)Δneo (also called Ai66(RCRL-tdT)-D, Ai66Δneo, or Ai66D) is a dual Dre/Cre recombinase fluorescent reporter. This Rosa-CAG-RoxSTOPRox-LoxSTOPLox-tdTomato::deltaNeo conditional allele is designed with both a Rox-flanked STOP cassette and a loxP-flanked STOP cassette preventing transcription of the tdTomato fluorescent protein. After removal of the flanked STOP cassettes by Dre- and Cre-recombination, tdTomato fluorescence is expected in cells/tissues expressing both Dre recombinase and Cre recombinase.

型号：GM-J#021875 -Available

应用：Ai65(RCFL-tdT)Δneo mice (also called Ai65(RCFL-tdT)-D, Ai65Δneo, or Ai65D) harbor the Rosa-CAG-FrtSTOPFrt-LoxSTOPLox-tdTomato::deltaNeo conditional allele designed with both an frt-flanked STOP cassette and a loxP-flanked STOP cassette preventing transcription of the tdTomato fluorescent protein. After removal of the flanked STOP cassettes by FLP- and Cre-recombination, tdTomato fluorescence is expected in cells/tissues expressing both FLP recombinase and Cre recombinase.

型号：GM-J#021830 -Cryorecovery

应用：This strain carries the D1994A point mutation in the Parkinson's disease-related Lrrk2 gene. The LRRK2 D1994A mutant protein has been shown to inhibit kinase activity.

型号：GM-J#021829 -Cryorecovery

应用：This strain carries the T1348N point mutation in the Parkinson's disease-related Lrrk2 gene. The LRRK2 T1348N mutant protein has been shown to inhibit GTPase activity.

型号：GM-J#021828 -Cryorecovery

应用：This strain carries the A2016T point mutation in the Parkinson's disease-related Lrrk2 gene. The Lrrk2 A2016T mutant protein has been shown to have normal kinase enzyme activity, but is resistant to certain kinase inhibitors.

型号：GM-J#021827 -Cryorecovery

应用：These loxP-flanked knockin mice carry an amino acid substitution, R1207H in exon 24, as well as loxP sites flanking exons 24 to 28 of the Eif4g1 gene. Mutations in Eif4g1, a translation initiation factor, are associated with susceptibility to Parkinson's disease.