产品型号:GM-J#027235 -Cryorecovery
产品应用:The tamoxifen-inducible Notch1 activation-dependent reporter knock-in allele, N1IP::CreERT2, has the endogenous Notch1 intracellular domain (NICD1) replaced with a 6xMyc-tagged, tamoxifen-inducible Cre recombinase (6mtCreERT2). Similar to the N1IP::CreLO allele, this N1IP::CreERT2 allele is predominantly expressed in cells in which moderate-to-high levels of sustained Notch activity or repeated activation cycles are known to occur (e.g., endothelium), with the added benefit that Cre recombinase activity is tamoxifen-inducible.