型号：GM-J#035978 -Cryorecovery

应用：Hoxb8-ICre knock-in mice express Cre recombinase from the mouse Hoxb8 (homeobox B8) promoter. Expression of Hoxb8 is not disrupted in this knock-in line. When used in combination with conditional reporter strains (e.g. Gt(ROSA)26Sortm1(EYFP)Cos Stock No. 006148), this strain allows you to visualize a subset of microglia for modulating anxiety.

型号：GM-J#035973 -Cryorecovery

应用：Rpe65CreERT2 knock-in mice have a P2A-CreERT2 coding region fused in-frame after the last amino acid-encoding codon of the endogenous retinal pigment epithelium 65 (Rpe65) gene. They are useful for studying gene function and pathophysiology of retinal diseases in the retinal pigment epithelium.

型号：GM-J#035926 -Cryorecovery

应用：Opn4CreERT2 knock-in/knock-out mice express cre/ERT2 under the direction of the Opn4 promoter. They are useful for applications requiring tamoxifen-induced deletion of floxed sequences in melanopsin-expressing retinal ganglion cells and amacrine cell layers of the retina.

型号：GM-J#035925 -Cryorecovery

应用：Opn4Cre knock-in/knock-out mice express Cre recombinase under the direction of the Opn4 promoter in melanopsin-expressing retinal ganglion cells and amacrine cell layers of the retina.

型号：GM-J#035901 -Cryorecovery

应用：Kcnma1fl-tdTomato conditional mutant mice possess loxP sites flanking exon 2 and a tdTomato reporter (that only expresses upon cre recombination) in the Kcnma1 (potassium large conductance calcium-activated channel, subfamily M, alpha member 1) gene and may be useful in generating conditional mutations to study the function of BK currents.

型号：GM-J#035878 -Cryorecovery

应用：MvhCre-mOrange (Ddx4-Cre) knock-in/knock-out mice express Cre recombinase from the mouse Ddx4 (DEAD box helicase 4; also called Mvh) promoter. An mOrange fluorescent reporter in the construct does not appear to be functional. Expression of Ddx4 is blocked. Cre recombinase activity is found in the gonads as early as embryonic day 1.5. Whole embryo recombination has been observed.

型号：GM-J#035877 -Cryorecovery

应用：MvhCre-mOrange (Ddx4-Cre) knock-in/knock-out mice express Cre recombinase from the mouse Ddx4 (DEAD box helicase 4; also called Mvh) locus. An mOrange fluorescent reporter in the construct does not appear to be functional. Expression of Ddx4 is blocked. Cre recombinase activity is found in the gonads as early as embryonic day 14.5. Variable whole embryo recombination has been observed.

型号：GM-J#035789 -Cryorecovery

应用：CAG-Stop-Dmrt1-Gfp knock-in mice conditionally express Dmrt1 (doublesex and mab-3 related transcription factor 1) and an EGFP reporter. This strain may be useful for studying vertebrate sex determination.

型号：GM-J#035764 -Available

应用：Jchain-CreERT2 knock-in mice have the endogenous immunoglobulin joining chain promoter/enhancer sequences directing expression of tamoxifen-inducible Cre recombinase, and are on a congenic C57BL/6N background. These mice are a Cre-lox tool allowing inducible Cre recombination with high specificity for B cells, and may be useful in studying immunology and infectious disease.

型号：GM-J#035717 -Available

应用：Il17aCre knock-in/knock-out mice express a codon improved Cre recombinase knocked into the endogenous Il17a gene. This targeted mutation abolishes Il17a expression. These mice may be useful for fate mapping IL17A secretion during T helper cell activation.