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  • 型号:GM-J#036293 -Cryorecovery

    应用:Lhx2-2A-CreER knock-in mice express tamoxifen-inducible CreERT2 fusion protein from the mouse Lhx2 (LIM homeobox protein 2) promoter in LHX2-positive cortical glutamatergic pyramidal neurons (PyNs).

    2024-11-09 点击次数:0

    型号:GM-J#036292 -Cryorecovery

    应用:Rosa26BEST1-CreERT2 knock-in mice have the human BEST1 promoter/enhancer sequences directing expression of tamoxifen-inducible Cre recombinase. These mice are a Cre-lox tool allowing inducible Cre recombination in BEST1-expressing cells/tissues (including cells of the retinal pigment epithelium and a small number of Muller glia), and may be useful in studying retinal development and pathologies.

    2024-11-09 点击次数:0

    型号:GM-J#036249 -Cryorecovery

    应用:Adora1-Cre knock-in mice are designed to have the endogenous Adora1 promoter/enhancer regions directing expression of Cre recombinase to multiple cell types, and in particular, providing high expression levels in neural cells. The cre knock-in results in minimal disruption to endogenous Adora1 (adenosine A1 receptor) expression. These mice are useful for studying body temperature regulation as well as cardiovascular and nervous systems.

    2024-11-09 点击次数:0

    型号:GM-J#036248 -Available

    应用:GS-CreER knock-in mice have the endogenous glutamate-ammonia ligase (glutamine synthetase) promoter/enhancer sequences directing expression of cre recombinase. These mice are a Cre-lox tool allowing cre recombination in Glul-expressing cells/tissues (primarily pericentral hepatocytes), and may be useful in studying hepatocyte proliferation, organization and function.

    2024-11-09 点击次数:0

    型号:GM-J#036247 -Available

    应用:Gls2-CreER knock-in mice have the endogenous Gls2 promoter/enhancer sequences directing expression of tamoxifen-inducible Cre recombinase. These mice are a Cre-lox tool allowing inducible Cre recombination in Gls2-expressing cells/tissues (including hepatocytes surrounding the portal vein in zone 1), and may be useful in studying hepatocyte proliferation, organization and function.

    2024-11-09 点击次数:0

    型号:GM-J#036246 -Available

    应用:Cyp1a2-CreER knock-in mice have the endogenous Cyp1a2 promoter/enhancer sequences directing expression of tamoxifen-inducible Cre recombinase. These mice are a Cre-lox tool allowing inducible Cre recombination in Cyp1a2-expressing cells/tissues (including hepatocytes surrounding the central vein in zones 2 and 3), and may be useful in studying hepatocyte proliferation, organization and function.

    2024-11-09 点击次数:0

    型号:GM-J#036235 -Cryorecovery

    应用:Cxcl12-creER transgenic mice express a tamoxifen-inducible (ERT2) codon-improved iCre recombinase directed by mouse Cxcl12 (chemokine (C-X-C motif) ligand 12) promoter elements. When induced, iCre recombinase activity is observed in a subset of bone marrow stromal cells. This strain may be useful for in vivo lineage tracing and functional analysis of skeletal regeneration.

    2024-11-09 点击次数:0

    型号:GM-J#036209 -Cryorecovery

    应用:Six3-CreERT2 (Six3+/-) knock-in/knock-out mice have cre/ERT2 cDNA replacing part of exon 1 of the sine oculis-related homeobox 3 (Six3) gene. They are useful for studying Holoprosencephaly (HPE).

    2024-11-09 点击次数:0

    型号:GM-J#036203 -Available

    应用:ER-BioIDHA (Secretome) knock-in mice have a CAG promoter controlling the Cre-inducible expression of a ER-BioID2HA fusion protein. Cre-mediated recombination results in the secretion of biotinylated proteins in a tissue-specific fashion when given exogenous biotin in their diet. These mice provide a genetic platform to delineate tissue-specific in vivo secretion.

    2024-11-09 点击次数:0

    型号:GM-J#036159 -Available

    应用:Gba1E326K mice carry a CRISPR/Cas9-generated E344K knock-in in exon 8 of the mouse Gba1 (glucosidase, beta, acid 1) gene. This mutation corresponds to a human coding variant potentially associated with increased susceptibility to familial Parkinson's disease. Homozygotes show ~30-40% reduction in glucocerebrosidase (GCase) activity in whole brain tissue as well as a decrease in the total protein.

    2024-11-09 点击次数:0
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