型号：GM-J#036313 -Available

应用：cNdufs2- (MCI-Park) mice were generated to inactivate Ndufs2 (NADH:ubiquinone oxidoreductase core subunit S2) specifically in dopaminergic neurons (Ndufs2fl/fl DATIREScre/+). Ndufs2 encodes a protein that contributes to the ubiquinone-binding site of mitochondrial complex I (MCI). Homozygous knock-out animals manifest clear, levodopa-responsive parkinsonism that is attributable to MCI dysfunction. In contrast to conventional Parkinson's disease (PD) models in which dopamine (DA) is depleted rapidly throughout the basal ganglia, the staging of pathology in these mice enables an assessment of how regional deficits in DA release are coupled to behavior.

型号：GM-J#036307-JAX -Cryorecovery

应用：These microRNA cluster 31(miRlet7c-2/7b) conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. LacZ expression is observed in embryonic brain and spinal cord. This mutant mouse strain may be useful in studies of microRNA biology.

型号：GM-J#036306-JAX -Cryorecovery

应用：These microRNA cluster 24(miR322) conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. This mutant mouse strain may be useful in studies of microRNA biology.

型号：GM-J#036305-JAX -Cryorecovery

应用：These microRNA 199a-1 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. This mutant mouse strain may be useful in studies of microRNA biology.

型号：GM-J#036304-JAX -Cryorecovery

应用：These microRNA 194-2 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. This mutant mouse strain may be useful in studies of microRNA biology.

型号：GM-J#036303-JAX -Cryorecovery

应用：These microRNA 188 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. This mutant mouse strain may be useful in studies of microRNA biology.

型号：GM-J#036303 -Cryorecovery

应用：Tis21-2A-CreER knock-in mice express tamoxifen-inducible CreERT2 fusion protein from the mouse Btg2 (BTG anti-proliferation factor 2; also called Tis21) promoter in BTG2-positive cortical glutamatergic pyramidal neurons (PyNs).

型号：GM-J#036302-JAX -Cryorecovery

应用：These microRNA 138-2 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. This mutant mouse strain may be useful in studies of microRNA biology.

型号：GM-J#036301-JAX -Cryorecovery

应用：These microRNA 137 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. This mutant mouse strain may be useful in studies of microRNA biology.

型号：GM-J#036301 -Available For Registering Interest

应用：Tbr2-2A-CreER knock-in mice express tamoxifen-inducible CreERT2 fusion protein from the mouse Eomes (eomesodermin; also called Tbr2) promoter in EOMES-positive cortical glutamatergic pyramidal neurons (PyNs).