型号：GM-J#037122 -Available

应用：The cre recombinase/green fluorescent protein fusion protein, driven by the Nr4a1 (Nur77) promoter in these mice, is expressed mainly in a subset of myeloid lineage cells of the spleen. These mice may be useful in studying thymocyte positive- and negative-selection as well as lymphocyte activation.

型号：GM-J#037103 -Cryorecovery

应用：Atoh13*HA-P2A-Cre knock-in mice carry a CRISPR/Cas9 generated insertion of three HA tags and Cre recombinase just upstream of the stop codon of the Atoh1 gene. These mice are useful for lineage tracing, cell sorting, and gene manipulation of multiple cell types including cochlear hair cells (HCs).

型号：GM-J#037095 -Cryorecovery

应用：TPO-cre transgenic mice express Cre recombinase under the control of the human TPO promoter. They may be useful when studying thyrocytes and the generation of thyroid hormones.

型号：GM-J#037071 -Cryorecovery

应用：MDRCas9 double mutant mice contain the 14qC3-MDR allele (Stock No. 017642), containing a loxP- and frt-flanked region on Chr 14 that has been implicated in B cell chronic lymphocytic leukemia (CLL). They also contain a Rosa26-LSL-Cas9 knockin allele (Stock No. 026175) with cre recombinase-dependent expression of CRISPR associated protein 9 (cas9) endonuclease and EGFP directed by a CAG promoter. When bred to MDRCD19 double homozygous mice (Stock No. 037070), these mice have applications in studies related to tumorigenesis and therapeutic management of chronic lymphocytic leukemia.

型号：GM-J#037070 -Cryorecovery

应用：MDRCD19 double mutant mice contain the 14qC3-MDR allele (Stock No. 017642), containing a loxP- and frt-flanked region on Chr 14 that has been implicated in B cell chronic lymphocytic leukemia (CLL). They also contain a Cd19cre allele (Stock No. 006785) with cre expression in B-lymphocytes during development and differentiation. When bred to MDRCas9 double homozygous mice (Stock No. 037071), these mice have applications in studies related to tumorigenesis and therapeutic management of chronic lymphocytic leukemia.

型号：GM-J#037052 -Available

应用：BAC-Sprr2f-Cre transgenic mice express Cre recombinase under the control of the Sprr2f promoter. They may be useful for driving expression of Cre specifically in endometrial epithelium.

型号：GM-J#037028 -Available

应用：CalcrCre mice have the endogenous calcitonin receptor (Calcr) promoter/enhancer sequences directing expression of Cre recombinase. These mice are a Cre-lox tool allowing Cre recombination in Calcr-expressing cells/tissues (including neurons of the nucleus of the solitary tract, hypothalamus, and lateral reticular nucleus) and may be useful for studying feeding behavior, obesity, and metabolism.

型号：GM-J#037018 -Available

应用：Removal of this mouse colony is imminent. If live mice are needed for your studies, it is advised that they be ordered immediately. After removal, the mice will be available from a cryorecovery.

型号：GM-J#037017 -Available

应用：CckarCre CRISPR-derived knock-in mice are designed to have 2A-Cre sequence inserted into the 3' UTR of the cholecystokinin A receptor (Cckar) gene. The endogenous Cckar promoter/enhancer regions direct expression of Cre recombinase to parts of the reproductive system, the central and peripheral nervous systems, and the gut, without disrupting endogenous gene expression. These mice are useful for studying mating behaviors, food intake, pancreatic exocrine secretion, gall bladder contractility and GI motility.

型号：GM-J#036980-JAX -Cryorecovery

应用：Mice homozygous for the null Dnajc6 or auxilin (DnaJ (Hsp40) homolog, subfamily C, member 6) allele exhibit high mortality at birth, decreased female fertility, an increase of assembled clathrin on vesicles and a decreased ratio of vesicle endocytosis at hippocampal synapses. This strain may be useful for studying synaptic vesicle recycling and early-onset Parkinson's.