型号：GM-J#017911 -Cryorecovery

应用：The Esr1cre knockin allele has Cre recombinase expression directed to estrogen receptor 1 alpha (Esr1 or ERα)-expressing cells by the endogenous Esr1 promoter/enhancer elements; specifically in the ventrolateral subdivision of the ventromedial hypothalamus that, like wildtype mice, is greater in females than males. Expression is also observed in arcuate nucleus (ARH). These Esr1-Cre knockin mice may be useful for studying the function of this ligand-inducible transcription factor in social interactions, neuronal differentiation, sympathetic nervous system development, hypothalamus, female reproductive organs (endometrium and ovarian stroma cells), and male efferent duct epithelial cells. They may also be useful for studying ERα-positive breast cancer and steroid hormone-induced malignancies. Esr1-Cre knockin mice are available on a C57BL/6N background (Stock No. 017911) and a C57BL/6J background (Stock No. 017913).

型号：GM-J#017909 -Cryorecovery

应用：The R26G-tTA2 allele has a CMV enhancer/chicken beta-actin core promoter-driven "MADM G-tTA2" (GFPN-terminus-intron-tTA2ATG-less) inserted into the Gt(ROSA)26Sor locus on chromosome 6. These mutant mice are designed to combine the "new MADM-6" system with a Tet-Off binary expression system to create MADM-Tet (mosaic analysis with double markers combined with Tet-Off). This is a tool to generate genetic mosaics in which an individual organism contains somatic cells of different genotypes. This allows Cre or FLP recombinase-induced fluorescent labeling/tTA2-expression in daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice are also a Tet-Off tool enabling a TRE transgene to be conditionally expressed in a subset of MADM-labeled cells.

型号：GM-J#017862 -Cryorecovery

应用：These pTH-ferritin transgenic mice exhibit increased ferritin-bound iron levels in the brain, decreased ferrous iron levels in the substantia nigra, and reduced sensitivity to MPTP-induced Parkinson's disease-like symptoms. They have applications in studies related to iron deficiency and Parkinson's disease.

型号：GM-J#017836 -Cryorecovery

应用：LGB-Cre (originally BLG-cre) transgenic mice have the beta-lactoglobulin promoter directing Cre recombinase expression to mammary gland during lactation. This strain may be useful for studying basal-like cancer and breast cancer, as well as providing a useful tool for testing new therapeutics.

型号：GM-J#017769 -Available

应用：These TRPV1Cre knock-in mice express Cre recombinase from the endogenous Trpv1 locus and may be useful for generating conditional mutations to study heat and capsaicin nociception or fate mapping of TRPV1 expression during development.

型号：GM-J#017763 -Available

应用：A CreERT2 fusion protein sequence inserted downstream of the Pax7 stop codon allows endogenous PAX7 expression in these mice while permitting specific conditional labeling, manipulation, and deletion of satellite cells.

型号：GM-J#017744 -Cryorecovery

应用：This PrPmtA transgenic strain expresses mutant human A53T alpha-synuclein (SNCA). Homozygotes may be a useful model for early stages of Parkinson's Disease, in particular to study the mechanisms of striatal synaptic plasticity, and may become a useful tool to study mechanisms of LevoDopa-induced dyskinesia.

型号：GM-J#017743 -Cryorecovery

应用：A CreERT2 fusion protein and β-galactosidase (lacZ) gene knocked into the ATG start codon of Prom1 abolishes gene function in these mice. Useful applications include visualizing and tracking adult stem cell lineages.

型号：GM-J#017738 -Cryorecovery

应用：Mice harboring the Foxl1-Cre transgene express Cre recombinase under the control of the mouse Foxl1, forkhead box L1, promoter, in the mesenchymal cells of the stomach and intestine, and in oval cells in injured liver. They may be useful for generating conditional mutations in gastrointestinal mesenchyme and liver progenitor cells.

型号：GM-J#017701 -Cryorecovery

应用：The Kiss1-CreGFP allele expresses a CreGFP fusion protein from the Kiss1 promoter/enhancer elements. These knock-in mice may be useful for visualizing KISS1 secreting neurons and for studying their role in fertility.