型号：GM-J#025208 -Cryorecovery

应用：The Entpd5G2aCE knock-in allele was designed to both abolish Entpd5 gene expression and express EGFP and Cre-ERT2 proteins from the Entpd5 promoter in proximal tubule cells of the mouse kidney.

型号：GM-J#025124 -Available

应用：These transgenic mice express a tamoxifen-inducible codon-improved Cre recombinase, iCre-ERT2, under the control of the Adipoq gene promoter. They may be useful in generating adipocyte-specific targeted mutants in studies related to adipose tissue function and storage, obesity, and other metabolic diseases.

型号：GM-J#025112 -Available

应用：Penk-IRES2-Cre knockin mice have Cre recombinase expression from the endogenous promoter/enhancer elements of the preproenkephalin locus. Cre recombinase activity is enriched in layers 2 and 6 of cortex and in restricted populations within olfactory areas, hippocampal formation, striatum, pallidum and hypothalamus. Scattered expression is also observed in thalamus, midbrain, pons, medulla, and cerebellum.

型号：GM-J#025110 -Cryorecovery

应用：Fezf1-2A-dCre-D mice express a trimethoprim-inducible Cre recombinase directed to Fezf1-expressing cells by the endogenous promoter/enhancer elements of the Fez family zinc finger 1 locus. When induced, small increases in Cre recombinase activity are observed in restricted populations within striatum and hypothalamus, as well as scattered positive cells in amygdala and cortex.

型号：GM-J#025109 -Cryorecovery

应用：The Ai80(RCFL-CatCh)-D (or Ai80D) conditional allele has both an frt-flanked STOP cassette and a loxP-flanked STOP cassette preventing transcription of the calcium translocating channelrhodopsin (CatCh; an L132C mutant channelrhodopsin with enhanced Ca2+ permeability, accelerated response kinetics and ~70-fold greater light sensitivity) and EYFP. After removal of the flanked STOP cassettes by FLP- and Cre-recombination, CatCh/EYFP expression is expected in cells/tissues expressing both FLP recombinase and Cre recombinase. Subsequent illumination of CatCh-expressing cells with blue-to-green light leads to reversible photostimulation of action potential firing/neural activity in these cells.

型号：GM-J#025106 -Available

应用：Ai75(RCL-nT)-D (also called Ai75D or Ai75(RCL-nls tdT)-D) mice display nuclear-localized tdTomato fluorescence following Cre recombinase exposure.

型号：GM-J#025105 -Cryorecovery

应用：When these CaMKIIα-tTA transgenic mice are mated to strain carrying a gene of interest under the regulatory control of a tetracycline-responsive promoter element (TRE; tetO), expression of the target gene can be blocked by administration of the tetracycline analog, doxycycline. These mice are a "Tet-Off" tool that allow the inducible expression of genes in forebrain neurons, and may be useful in studying brain disorders such as Alzheimer's, Parkinson's, Huntington's, or other neurodegenerative disease.

型号：GM-J#024968 -Cryorecovery

应用：This tamoxifen-inducible Pdx1-Cre/Esr1 strain may be used to create conditional pancreatic cell knockouts when crossed with strains carrying floxed alleles.

型号：GM-J#024948 -Cryorecovery

应用：The GdnfCreERT2 allele expresses GDNF and tamoxifen-inducible CreERT2 in self-renewing, multipotent renal progenitor cells. These mice may be useful for studying the role of GDNF on ureteric bud branching and fetal nephron numbers in the developing kidney.

型号：GM-J#024926 -Cryorecovery

应用：These mice express Cre recombinase under the control of a truncated follicle stimulating hormone receptor (Fshr) promoter in ovarian granulosa cells and in cells from the anterior pituitary.