型号：GM-J#000544 -Cryorecovery
应用：These mice carry a spontaneous mutation at the Cacna1a locus characterized by a wobbly gait and intermittent, spontaneous seizures.
型号：GM-J#000506 -Cryorecovery
应用：These mice carry a spontaneous mutation at the Qki locus characterized by a rapid tremor that increases during locomotion.
型号：GM-J#000247 -Cryorecovery
应用：Mice homozygous for the weaver spontaneous mutation (Kcnj6wv) are recognizable in the second postnatal week by their small size, instability of gait, weakness, and hypotonia. Many homozygous mutant mice die at weaning age, but some survive to adulthood, and females may breed. The cerebellum in homozygous mutants is very small, simple, and almost devoid of granule cells, which degenerate during the second week. Heterozygotes behave normally, but they have a smaller than normal cerebellum with a deficiency of granule cells, some of which fail to migrate into the internal granule layer and remain scattered in the molecular layer. Evidence from cultures of mutant and normal cerebellum show that granule cells of Kcnj6wv/Kcnj6wv and Kcnj6wv/+ mice have gene-dosage dependent abnormalities in morphology and cell behavior. Studies using homozygous weaver/wildtype chimeras indicate that the migration defect of granule cells is intrinsic to the granule cells themselves. The disarrangement of Purkinje cells, however, is not caused by intrinsic action of weaver in these cells. Cell mixing experiments also suggest Kcnj6wv acts non-autonomously and encodes a membrane-associated ligand that induces external germinal layer neuron differentiation.
型号：GM-J#000231 -Cryorecovery
应用：Mice homozygous for the osteopetrosis spontaneous mutation (Csf1op) may be useful to study the role of glia in neurological disease.
型号：GM-ZY008-3-8W
应用：通常用于研究CD8+T细胞对抗原的反应、阳性选择，以及在任何需要具有特定特异性的CD8+T细胞的研究中。
型号：GM-ZY007-3-8W
应用：5XFAD转基因小鼠重现了阿尔兹海默症淀粉样蛋白病理的主要特征，可作为神经元内Aβ-42诱导的神经退行和淀粉样斑块形成的模型。
