产品型号：GM-J#002609 -Available

产品应用：Nos2tm1Lau homozygotes, unlike Nos2 wildtype mice, have virtually no serum nitric oxide response, but were susceptible to LPS-induced death. Nos2tm1Lau homozygotes exhibit altered responses to M. bovis (BCG), systemic E. coli infection, M. tuberculosis and M. pulmonis. In addition, wound healing properties of fibroblasts are impaired in Nos2tm1Lau homozygotes. These mice may be suitable for use in studies of inflammatory conditions including rheumatoid arthritis, inflammatory bowel disease, cardiac allograft rejection, hepatoxicity, myocardial ischemia-reperfusion and septic shock.