产品型号：GM-J#018786 -Cryorecovery

产品应用：Mice hemizygous for the BAC LRRK2(R1441G) transgene are viable and fertile, with expression of a mutant form of human leucine-rich repeat kinase 2 (LRRK2*R1441G) associated with autosomal dominant, late-onset Parkinson's disease directed by the human LRRK2 promoter/enhancer regions on the BAC transgene. These LRRK2(R1441G) mice represent an in vivo model for studying the Parkinson's disease pathogenesis and neurodegeneration elicited by the dominant toxic effects of mutant LRRK2(R1441G) expression.