产品型号：GM-J#010799 -Available

产品应用：These double transgenic homozygous mice (dbl-PAC-Tg(SNCAA53T);Snca-/- mice) harbor a Snca knock-out allele and two independently inserted transgenes encoding the human A53T-mutant α-synuclein associated with autosomal dominant Parkinson's disease. The very early gastrointestinal dysfunction in the absence of major central nervous system pathology in dbl-PAC-Tg(SNCAA53T);Snca-/- mice mimics what is seen early in human Parkinson's disease, when enteric nervous system dysfunction may precede the more classical motor symptoms by years to decades.